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In the first set of experiments, 24 animals were used to monitor the survival rate during 12 days

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On the contrary, O-to-S exchange dramatically boosted the inactivation rates of both analogues: the -chlorothioacetamide 14 reached a k inact of 8.3 10 -1 s, yielding the highest efficiency (k inact /K I = 2.5 10 6 Ms) among the series despite its slightly reduced binding affinity (K I = 3.3 10 7 M)

Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital

Berry SH, Elliott MN, Suttorp M, et al