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The CV safety of a lower dose of liraglutide (1.8 mg, Victoza, Novo Nordisk) in people with T2D was established in the Liraglutide Effect and Action in Diabetes: Evaluation of CV Outcome Results (LEADER) study, showing a 13% reduction in major CV events over an average of 3.8 years [44]

Together, these foundational studies elucidated NRF2-ARE-induced genes involved in glutathione production and activity

Statistical differences between groups for all evaluations, except for FST, which was assessed using the Kruskal-wallis test, were analyzed using one-way analysis of variance (ANOVA)

Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

Am J Physiol Gastrointest Liver Physiol 2023;325:G42-G61