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Once it happens, the methionine residue has permanently changed, and the peptide may no longer function as intended

Data availability The cryo-EM data generated in this study have been deposited in the PDB and in the EM data bank under accession codes 8A1R and EMD-15084, respectively

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Both compounds share the same regulatory timeline: moved to Category 2 in 2023, removed from Category 2 in April 2026, and scheduled for PCAC review on July 23, 2026

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