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Weight loss itself is known to reduce the risk of heart disease, so combining it with a medication like aspirin, which supports cardiovascular health, may offer extra protection

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Sustainable dietary quality, adequate protein intake, resistance exercise, good sleep, and stress management all support retatrutide's effectiveness alongside pharmacological treatment

During perimenopause and menopause, hormonal changes can influence metabolism, body composition, fat distribution, and appetite, making it more difficult to lose weight through diet and exercise alone