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Compared with semaglitude 1 mg, treatment with tirzepatide demonstrated reduced glucagon secretion in response to mixed meal, suggesting an additive effect compared to GPL1 RA on glucagon suppression

Additional studies suggest its potency in wound healing as well, which can further support gut health

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These receptor configurations are commonly referred to as AMY1, AMY2, and AMY3 receptors and are distributed throughout tissues involved in nutrient sensing, gastrointestinal physiology, and central nervous system signalling

This dual approach can lead to more substantial weight loss and improved glycemic control compared to either medication alone