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Individuals with XPA pathogenic variants in the DNA binding region (amino acids 98219) may have a more severe presentation that includes neurological findings.[68] Individuals within the XPC complementation group have higher incidences of ocular damage.[67] A very small number of people in the XPB, XPD, and XPG complementation groups have been identified as having xeroderma pigmentosum-Cockayne syndrome (XP-CS) complex