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Polymorphism in GSTP1 due to A to G transition at nucleotide 313 (A313G) of the coding region (rs1695) leads to substitution of 105 th amino acid isoleucine (Ile) with valine (Val)

It can also be oxidised into an inactive form unless it is manufactured with an enteric-coating or the SAMe itself is microencapsulated

Based on published literature, common research applications include: Metabolic and Glucose Pathway Research: Investigating how MT2 injection into specific hypothalamic nuclei (like the ventromedial hypothalamus) increases glucose uptake in skeletal muscle and brown adipose tissue, offering models for diabetes pathogenesis research

doi: 10.1080/10715760000300891 64 MuriJThutHBornkammGWKopfM

Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences [Internet]