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A study indicated that the activation of both ERK and p38MAPK pathways is crucial in the process of Nrf2 nuclear translocation and HO-1 gene activation triggered by DAS (169)

Without glutathione, then, this feedback inhibition is removed, and there is an upregulation of this enzyme, resulting in increased amounts of gamma-glutamyl cysteine, which itself is a precursor to the organic acid 5-oxoproline

Figure 2: Results of a Western Blot Analysis, used to assess the purification of c-myc by immunoprecipitation

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Archived from the original on 2013-03-07