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doi: 10.4103/ijn.IJN_389_20 61

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Fluorescence intensity measured in negative controls (samples without BHZ incubation) was averaged and subtracted from sample measurements to adjust for background in the bar graphs

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In addition, aberrant Ca 2+ signaling causing mitochondrial dysfunction can adversely affect neurotransmitter signaling and lead to excitation/inhibition imbalance [94, 97, 98]

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Notably, Smad3 , which acts primarily downstream of the TGF-activin pathway and is predicted to drive early gene expression changes in HD 23 , was significantly upregulated in the iSPN + mut subpopulation at 8 months (Extended Data Fig

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