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Carbone G, Wilson A, Diehl SA et al (2013) Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis

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Moreover, HMGB1 passively released from necrotic cells, binds to toll-like receptor 4 (TLR4) on DCs, facilitates their maturation and the effective presentation of tumor antigens to T cells