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They stimulate insulin secretion in response to meals, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

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In patients with type 2 diabetes, cardiovascular benefits have been observed with GLP-1 receptor agonists, including liraglutide in the LEADER trial and semaglutide in SUSTAIN-6

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At the same time, some evidence suggests that certain GLP-1 drugsespecially semaglutidemay be associated with temporary worsening of diabetic retinopathy in patients who already have retinal disease, particularly when glucose improves quickly