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GLP-1R agonists were initially used to treat T2DM and soon after it was found that these drugs possess many other physiological properties, such as neuroprotection, neurotrophic, and anti-inflammatory effects, which may be useful to slow the progression of AD ( Figure 3 ) ( Figure 3 Anti-inflammatory effects Previous studies have shown that GLP-1R mimics have anti-inflammatory effects in the CNS (139141)

Various cytokines can also impact vascular function and structure, as well as renal sodium transport, ultimately resulting in increased systemic vascular resistance, elevated blood pressure, and sodium and volume retention [214, 215]

21 At the neural level, GLP-1RAs activate CCK-expressing neurons in the NTS and area postrema, brain regions associated with appetite suppression and nausea

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An employee who enrolls in a qualified High Deductible Health Plan (HDHP) mid-year can open and contribute to a HSA Contribution Limits Could Double in 2026 for Millions Under the Recently Passed H.R