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Exploration of GSH-degrading enzyme modulators presents a promising avenue for impeding cancer progression, overcoming tumor resistance to pro-oxidative therapy and preserving tumor sensitivity to chemotherapy (Table III)

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Exp Neurobiol 22:1117 Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease

The NADPH generated during this step is a potent reducing agent, serving as a critical factor in various cellular redox reactions