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Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study

In principle, this is not surprising, because models of complex diseases such as brain diseases, as a rule, either involve some of the known mechanisms of the pathogenesis of these diseases, or simply mimic individual symptoms, but never fully reproduce the pathogenesis and symptoms of the disease

As GLP-1-based therapies grow in prominence (especially with obesity and NASH indications), the regulatory dynamics between major regions will become increasingly strategic

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