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Last year, FDAacting through the Office of Prescription Drug Promotion (OPDP) within the Center for Drug Evaluation and Research (CDER)issued a high volume of untitled and warning letters as part of a broader push against directtoconsumer (DTC) drug advertising, including 58 letters addressing claims about compounded GLP1s (e.g., semaglutide and tirzepatide) and other compounded products (e.g., sildenafil and tadalafil).[2] By mid2026, activity appeared to taper offraising the question whether FDA had shifted priorities, for example due to personnel changes, or simply paused the effort

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This clearly highlights GLP-1RAs as promising agents for the management of MASLD