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It is produced by the kidneys, liver, and pancreas and can also be found in low quantities in red meat and fish (OPSS, 2025)

Treatment is typically administered once weekly, and your provider will determine the appropriate dosage and schedule based on your individual needs

Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohns disease features skip lesions areas of diseased bowel separated by segments of normal-appearing tissue and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohns & Colitis Foundation

doi:10.1042/bj2640437

Here are five important takeaways