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According to the guidelines for the primary care of hypothyroidism (2019) [7], individuals experiencing mild SCH accompanied by symptoms of hypothyroidism, thyroid peroxidase antibody (TPOAb)positivity, dyslipidemia, or atherosclerotic disease should receive levothyroxine (L-T 4 ) treatment

Additionally, the condition can sometimes alter how the body processes fats and fat-soluble vitamins, making it harder to maintain optimal Vitamin D levels without focused supplementation

By weeks 2-3, the immune system has had time to clear the initial wave of apoptotic senescent cells

These abnormal changes in metabolite levels reflect dysfunction within the gut microbiome of PCOS patients and play a crucial role in the progression of the disease

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