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The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly

Retatrutide 5mg Dosing & Observed Effects in Research In research settings, retatrutide is typically studied at doses between 1 mg and 12 mg , usually given once a week through subcutaneous injections