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Body weight and composition can influence drug distribution and pharmacokinetics

In the alpha cells of the islets, GLP-1 receptor activation suppresses glucagon secretion, a process mediated by somatostatin release from adjacent delta cells.54,57 Beyond the pancreas, GLP-1 receptors are widely expressed in extrapancreatic tissues, including the heart, vascular smooth muscle, lungs, liver, gastrointestinal tract, vagus nerve, and enteric nervous system.58 GLP-1 receptor agonists exhibit varying degrees of homology with endogenous GLP-1 but possess extended durations of action

[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Kendzerska T, Gershon AS, Hawker G, Tomlinson G, Leung RS

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In contrast to the effects of sweet taste on GLP-1 release, glucagon secretion decreases in response to sweet taste perception, indicating that glucagon is expressed in a different population of type II taste buds than those that express GLP-1 and GLP2 (67)