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followed by Eli Lillys drug Mounjaro, FDA approved to treat Diabetes in 2022

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TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility

Ferroptotic cells exhibit characteristic features including outer mitochondrial membrane rupture, unusually small mitochondria, and less pronounced or even absent cristae ( Yes-associated protein (YAP) is a downstream transcriptional activator in the Hippo pathway that controls the survival and proliferation of cardiomyocytes and many other cells, regulating a diverse array of oxidative stress- and apoptosis-related pathological and physiological activities ( Pyrroloquinoline quinone (PQQ) is a natural water-soluble redox coenzyme that is found throughout plant and animal tissues, serving as an essential nutrient in mammals with purported cardioprotective activity ( In light of the above evidence, the present study was developed with the hypothesis that PQQ may act as a cardioprotective agent to prevent heart failure via modulating YAP-related anti-ferroptotic activity, thus reducing the severity of myocardial hypertrophy