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As shown in Figure 9B, the common targets of main ingredients and AD in FRP are mainly enriched in signal transduction, positive regulation of transcription from RNA polymerase II promoter, protein phosphorylation, negative regulation of the apoptotic process, response to the drug, positive regulation of gene expression, positive regulation of cell proliferation, response to xenobiotic stimulus, positive regulation of transcription, DNA-templated, positive regulation of MAPK cascade

American Dietetic Association, Dietitians of Canada

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Along this conduit, the brain interacts with the gut through neural components (CNS and ANS), endocrine system (hypothalamic-pituitary-adrenal axis), immune components (cytokines and metabolic) and gastrointestinal components (microbiota, intestinal barrier and intestinal immune response) (Owicimska et al., 2017)

Its amount depends on the diet, level of physical activity, lifestyle and age