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In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear

Last reviewed June 30, 2026

Having a pouch and wanting to reduce the frequency of bowel movements per day (for example) would not qualify a patient for a prescription according to the licensed indications

doi: 10.1038/npp.2015.47, 61 HealthU

Bone health is also a concern with GLP-1 medications, especially for women in menopause who are already at risk for bone loss