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The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-hydroxydopamine (6-OHDA), and 5-S-cysteinyl-dopamine (CysDA) models each target dopaminergic neurons and increase oxidative damage to the brain, providing valuable insight to the efficacy of mitigating oxidative stress as a mechanism of sulforaphanes neuroprotective effects

Patients with retinopathy should have ophthalmologic monitoring, particularly when also using insulin

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While the medication has been shown to be effective in improving glycemic control and promoting weight loss, there have been reports of negative mood changes associated with its use