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Besides inducing the transcription of endogenous antioxidant enzymes, Nrf2 affects the homeostasis of ROS and reactive nitrogen species (RNS) through regeneration of oxidized cofactors and proteins

It was hypothesized that such expansion might have occurred during adaptation to environmental selection pressure

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They also boost pulsatile growth hormone release, which may have different effects than the sustained receptor start achieved with IGF1 LR3

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