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B12 is water-soluble, meaning your body excretes what it doesn't need rather than storing it to potentially harmful levels

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Monitoring, Dose Adjustment, and When to Pause Treatment Warning signs include persistent severe nausea, vomiting that prevents food or fluid intake, abdominal bloating unrelieved by position change, or inability to tolerate any oral intake after two weeks of stable dosing

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Starting at the lower end allows assessment of individual response before increasing if needed