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For example, high-fat feeding alters the small intestinal microbiota to increase intestinal, brain, and circulatory levels of taurine-conjugated bile acids, including and taurochenodeoxycholic acid (TCDCA), which is an FXR agonist 272

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Your liver normally neutralizes this with a substance called glutathione , but heavy alcohol use depletes glutathione levels, reducing your livers ability to process the toxin