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In the UK, these higher-dose formulations are available through specialist weight management services for people meeting specific BMI thresholds and with weight-related comorbidities, as outlined in NICE technology appraisals

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According to FDA prescribing information, these effects vary by product and dose: For Ozempic (diabetes treatment): Nausea (15-20% of patients) Diarrhea (8-9% of patients) Vomiting (5-9% of patients) Constipation (3-7% of patients) Abdominal pain (5-6% of patients) For Wegovy (weight management), gastrointestinal effects are more common at the higher therapeutic dose: Nausea (up to 44% of patients) Diarrhea (up to 30% of patients) Vomiting (up to 24% of patients) Constipation (up to 24% of patients) Abdominal pain (up to 20% of patients) These effects are generally mild to moderate and tend to diminish with continued use

DM is characterized by elevated blood sugar (glycemic) levels, therefore the role of these drugs is to reduce glycemic levels, possibly avoiding hypoglycemic events

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