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In contrast to the effects of Rac1 and Cdc42, the expression of constitutively active RhoA in hippocampal neurons or slice cultures consistently resulted in simplified dendritic trees and reduced spine density (Nakayama et al., 2000

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A small pilot study designed to evaluate the safety of lipoic acid in 30 people with relapsing or progressive multiple sclerosis found that treatment with 1,200 to 2,400 mg/day of oral lipoic acid for two weeks was generally well tolerated (see Safety) (95)

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Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice