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Origins as a Mitochondrial-Derived Peptide MOTS-C peptide was first characterized in 2015 by Lee and colleagues, who showed that stressed muscle cells release this peptide, which then translocates to the nucleus to upregulate genes involved in adaptive stress resistance

Kahar, S

Moreover, a favorable impact of GLP-1RAs on cardiac remodeling can occur through activation of the eNOS/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) nexus [72]

Studies have also shown that SMURF1 promotes autophagy through the p62/LC3 autophagy pathway to maintain cell homeostasis [54]

Ki-67 immunofluorescence staining HUVEC cells were seeded on confocal culture dishes (1 10 5 cells per well) and incubated with different materials for 24 h