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Most researchers use 4-6 week breaks between 16-week cycles

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Cambridge University Press

Oral vitamins must get broken down by the GI tract (through the stomach, and intestines) and then go through the liver for metabolizing

GE2 treatment increases neurogenesis in the dorsal hippocampus depending on sex and diet WD reduced the density of DCX-expressing cells compared to SD ( p = 0.024, Cohens d = 1.309), but only in males, and GE2 treatment normalized the density of DCX-expressing cells under a WD in males ( p = 0.008, Cohens d = 4.023