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However, the widespread expression of NMDA receptors and their broad excitatory effects raise concerns that global inhibition could result in side effects such as ataxia, impaired learning, and psychosis [99]

The animals were then deeply anesthetized with 3% isoflurane and 50 mg/kg of ketamine followed by a laminectomy at lumbar level L2-L3, corresponding to the sacrocaudal spinal cord