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Nerve Dependence on Metabolism: Peripheral nerves require specific nutrient levels Dramatic metabolic changes may temporarily affect nerve function Similar to diabetes causing neuropathy (but reversed mechanism) Weakness of Theory: Improving metabolic health should help nerves, not harm them

Despite a significant improvement in the treatment of T2D and CVD over the past few decades, reducing CVD in patients with T2D solely with an optimal glycemic control has been challenging [2]

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however, it ultimately backed away from providing therapy services