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Adding complexity to the study of these receptors, there is extensive species-specificity, so that animal findings result in poorly translatable data, requiring the generation of complex human-murine chimera currently under intense study (305, 306)

On the highest dose, 86% of people lost at least 5% of their body weight, 70% lost at least 10%, and 38% lost at least 15%

Body composition advantages from muscle preservation become most apparent after 3-6 months when total weight loss is substantial enough for the lean mass preservation to show on DEXA scans

Products promising dramatic or rapid results without lifestyle change should be approached with considerable scepticism

They can help to: Reduce hunger and cravings