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256,257 The SASP secreted by senescent cells can also influence adjacent cells, including promoting tumor cell migration and metastasis, as well as facilitating angiogenesis and lymphangiogenesis by recruiting specific macrophages

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In aged Rhesus monkeys, Epitalon treatment stimulated melatonin production and restored youthful secretion patterns, while also normalizing cortisol rhythms in a time-of-daydependent manner [59]

The pharmacokinetic parameters were measured in non-human primates