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84 To increase patient adherence, danugliprion will be studied in a once daily formulation

After being stimulated, neurons of the paraventricular nucleus of the hypothalamus release corticotropin-releasing hormone (CRH), which will be transported by hypothalamic-pituitary portal circulation and stimulate pituitary corticotroph cells to cleave proopiomelanocortin (POMC) in adrenocorticotrophic hormone (ACTH) [12]

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This was consistent with the morphological characteristics of MNTI

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