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While anyone can benefit from healthy B12 levels, certain groups are more likely to experience deficiencies and may see greater advantages from supplementation: Vegans and vegetarians: B12 is primarily found in animal products, making supplementation critical for those on plant-based diets

Consistent with the observed PO-like upregulation, high PO activities have been documented in lesions associated with white syndrome disease in an Indo-Pacific coral species (Palmer et al

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Tocilizumab, an IL-6 receptor (IL-6R) antagonist, has been shown to stimulate the bone formation marker P1NP while inhibiting bone resorption markers CTX-1 and ICTP after four weeks of treatment (101)