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Each subsequent puncture of the stopper increases that risk exponentially

Clin Immunol (2018) 197:15460

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doi: 10.3389/fendo.2024.1429884 Received 08 May 2024 Accepted 28 May 2024 Published 19 June 2024 Volume 15 - 2024 Edited by Mariacarolina Salerno, University of Naples Federico II, Italy Reviewed by Malgorzata Gabriela Wasniewska, University of Messina, Italy Marek Niedziela, Poznan University of Medical Sciences, Poland Updates Copyright 2024 Street, Shulhai, Petraroli, Patianna, Donini, Giudice, Gnocchi, Masetti, Montani, Rotondo, Bernasconi, Iughetti, Esposito and Predieri

And excessive accumulation of ROS in turn affect the metabolic reprogramming (45, 46)