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Be aware that a similar connection with TMAO and cardiovascular disease risk has been made for L-carnitine from red meat and, possibly, from supplements with L-carnitine, including acetyl-L-carnitine see the Concerns and Cautions section of the Acetyl-L-Carnitine Supplements Review for details

However, the relationship between improved glycemic control and cognitive function is complex, as demonstrated by mixed results in large trials like ACCORD-MIND