Effect of Ang II on medullary RBF Ang II elicits a paradoxical medullary vasodilatation in normotensive animals, mediated by a secondary activation of vasodilator paracrine agents such as prostaglandins, kinins and NO, rather than to a direct action via AT 2 receptors
Think of it as both a copper delivery system and a gene modulator : Copper is essential for enzymes that build collagen, defend against oxidative stress, and produce cellular energy
Berberine 500mg + Curcumin 500mg + Chromium Picolinate 200mcg taken daily can yield 5-7lb loss plus A1C reduction of -0.9% through synergistic effects on insulin sensitivity and GLP-1 production
When paired with strategic meal timing, this diet can enhance the effects of GLP-1 medications by stabilising blood sugar levels and promoting satiety
Thus, for those who struggle to afford these therapies, its a way to access some of the benefits of GLP-1s without the financial burden