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Jutkowitz E, Gozalo P, Trivedi A, Mitchell L, Gaugler JE

Additionally, vitamin B12 injections can be used in conjunction with oral supplements and fortified foods to maintain adequate vitamin B12 levels

While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency

Cooper, G

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