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Regular physical activity , even when feeling tired, can paradoxically improve energy levels

Notably, this mechanism does not rely on the hypothalamic-pituitary-adrenal axis (HPA axis) or lipid-mediated inflammatory regulation but instead regulates inflammatory factor expression through neuroendocrine pathways mediated by activation of 1-adrenergic receptors and and -opioid receptors, thereby exerting an immunosuppressive effect [52]

For ANOVA, Tukey post-hoc analyses were performed to identify specific differences

We obtained citations for this publication through searches of PubMed up to April 2024, with no lower limit set for the date, using both MeSH and free-text terms to identify relevant articles

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