Dosing, administration routes, timing, cycling, and storage all affect outcomes in ways that the research literature does not always make explicit
Subsequently, molecular feedback loops are activated to counter the negative consequences
Chem Sci 2(11):21352142 Shukla P, Choudhury KK, Kajol BS, Panigrahy J, Pathak RK (2025) Front Cover: Development of a Tumor Microenvironment-Responsive Co (III)-Chrysin Prodrug: Synthesis, Activation Profiling, and In Vitro Antineoplastic Evaluation (ChemMedChem 20/2025)
This is due to the increased levels of cytokines that induce characteristic alterations in positive and negative APPs in the liver [44]
Huang ZZ, Li H, Cai J, Kuhlenkamp J, Kaplowitz N, Lu SC