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As seen in males, AgRP GHR KO females showed an attenuated increase in hypothalamic AgRP and NPY mRNA levels during F.R., whereas POMC gene expression was not affected by GHR ablation (Supplementary Fig

This systems-level strategy facilitates the identification of biomarkers and therapeutic targets that may be missed by single-omics analyses, offering novel insights into functional heterogeneity and opportunities for precision interventions

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