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If a significant part of this mechanism relies on re-absorption from bile that would be an issue due to lack of intrinsic factor breaking the "enterohepatic recirculation"

47,48,49,50,51,52,53,54 All these studies used injectable B12, most commonly given intravenously (i.v.) after HD twothree times per week, and the most common dose was 1000 g per injection

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Freeze at -20 degrees Celsius only for long-term storage of vials that will not be opened for an extended period, and avoid repeated freeze-thaw cycles

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