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It draws a line between mild to moderate nausea and constipation, which it treats as manageable with time and provider guidance, and these symptoms, which need prompt evaluation

In human, subjects given a continuous intravenous infusion of GLP-1, post-prandial concentrations of glucose, glucagon, and insulin progressively increased in subsequent meals

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Sorli C, Harashima SI, Tsoukas GM et al (2017) Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

Pattern matters as much as amount