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As incretin therapies are relatively costly, cost-effectiveness studies will need to demonstrate in which high-risk population the use of incretins should be prioritized, especially in those without diabetes, where data remain scant

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The fixed-dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg pairs a GLP-1 receptor agonist with a long-acting analogue of amylin, a pancreatic hormone that reduces appetite and slows gastric emptying