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This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis but also reveals a weight loss-independent repair mechanism that targets metabolic pathways and mediators essential to cartilage repair under osteoarthritis conditions, the study authors wrote

The increased demands of growing tumors in nutrients and oxygen triggers the formation of new blood vessels, a process called angiogenesis

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10.3920/BM2012.0046 Benef Microbes 207 TurnbaughP

Ketogenic diets are known to influence gut microbial composition and xenobiotic metabolism, and the observed decline may reflect changes in dietary exposure, microbial activity, or hepatic clearance