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[DOI] [PubMed] [Google Scholar] 27.Geethangili M, Lin CW, Mersmann HJ, Ding ST

A loss of 0.5-2 pounds per week is a healthy and sustainable rate

Fatigue and cognitive fog tend to become pronounced by day three or four as glycogen stores deplete and the body struggles to find stable fuel in the absence of fat or protein

The half-lives of unbound IGF-1, IGF-1 in a binary complex, and IGF-1 in a ternary complex are less than 10 minutes, 25 minutes, and more than 16 hours respectively meaning that IGF-1 activity is tightly regulated by its binding proteins