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Introduction Choline is an essential nutrient for humans and acts as a precursor for the neurotransmitter acetylcholine and membrane lipids such as phosphatidylcholine (PC) and sphingomyelin through the Kennedy pathway (1, 2, 3, 4, 5) (Fig 1A)

Most genetic diseases associated with PDHc deficiency are due to mutations in either of the two subunits ( encoded by the PDHA1 gene or encoded by the PDHB gene) of the functional PDH heterotetramer of the PDHc

Pharmacol Res (2018) 128:31521

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As there is limited available research on this material, improper handling or consumption may lead to adverse effects