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They can exhibit different phenotypes or polarization states, broadly classified as pro-inflammatory (M1) or anti-inflammatory (M2)

Primary astrocytes were crosslinked with 1% formaldehyde for 20 min at 37 C and quenched in 0.125 M glycine

Thirdly, the structure of ChaC1 is not known, and efforts to solve the structure have been hampered by the strong tendency of ChaC1 to aggregate in vitro

Ethics declarations Competing interests The authors declare the following competing interests: A.R., M.H., L.B., J.J.S., A.D., M.S., and C.K

Berberine , a plant alkaloid that lowers blood glucose and cholesterol through AMPK and is often called natures metformin, has no clinical evidence for cognition or neuroprotection, only animal work